EPSRC Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines

 
University of Nottingham
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Sarah Trenfield

CDT student, UCL School of Pharmacy

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Sarah Trenfield
 
Biography

Sarah qualified with a first class honours MPharm degree from Cardiff University in 2015. She undertook a pre-registration pharmacist year at Merck, Sharpe and Dohme (MSD) split with Guy's and St. Thomas' Hospital NHS Foundation Trust. At MSD, Sarah's main projects involved investigating the root causes of scuffing on film-coated tablets, as well as authoring a book chapter on formulation selection in first-in-human clinical trials. In 2016, Sarah successfully registered as a pharmacist and begun the CDT scheme at UCL. Sarah's first mini-project with the CDT was titled 'Metal organic frameworks as novel vaccine adjuvants'. Sarah then completed a placement at Pfizer where she worked on 'The evaluation of compression force on coated pellets in orally-disintegrating tablets'. Sarah is now undertaking her PhD in 3D printing of solid oral dosage forms, supervised by Prof. Abdul Basit and Prof. Simon Gaisford.

 
Current Research

PhD Project Title: Development of 3D printing technology for in-situ verification of dose

Supervisor: Prof Abdul Basit

Project description: Sarah's PhD is focussed on 3D printing of solid oral dosage forms. In particular, this project aims to investigate and implement a non-destructive method for drug identification and quantification in 3D printed tablets. The main aims of Sarah's project include the following: 1) Examine a range of in-situ analytical techniques that could be incorporated into a 3D printer platform (e.g. NIR/Raman spectroscopy, balances, colorimetric methods); 2) Modify the 3D printer to include the analytical techniques described; 3) Demonstrate that the modified printer is fit-for-purpose by manufacturing a range of dosage forms and devices. This project will contribute towards establishing an acceptable means of quality control for 3D printed pharmaceuticals, which is a current barrier to clinical integration.

 
Publications

Trenfield S, Goyanes A (2019) Shaping the future: The Power of 3D Printing Pharmaceuticals, Innovations in Pharmaceutical Technology  68, 12-14. www.iptonline.com, Discovery Technology

Awad A, Fina F, Trenfield SJ, Patel P, Goyanes A, Gaisford S, Basit A W (2019) 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology,  Pharmaceutics, 11, 148 https://doi.org/10.3390/pharmaceutics11040148

Trenfield SJ, Madla CM, Basit AW, Gaisford S (2018) 3D printing of pharmaceuticals: Binder jet printing in pharmaceutical manufacturing, Springer International Publishing https://doi.org/10.1007/978-3-319-90755-0_3

Madla CM, Trenfield SJ, Basit AW, Gaisford S (2018)3D printing of pharmaceuticals: 3D printing technologies, implementation and overview, Springer International Publishing https://doi.org/10.1007/978-3-319-90755-0_2

Trenfield SJ, Madla CM, Basit AW, Gaisford S (2018)3D printing of pharmaceuticals: The shape of things to come: Emerging applications of 3D printing in healthcare, Springer International Publishing  DOI https://doi.org/10.1007/978-3-319-90755-0_1

 Afonso-Pereira F, Dou L, Trenfield SJ, Madla CM, Murdan S, Sousa J, Veiga F, Basit AW (2018)Sex differences in the gastrointestinal tract of rats and the implications for oral drug delivery, European Journal of Pharmaceutical Sciences; 339:344 doi: 10.1016/j.ejps.2018.01.043.

Vuddanda PR, Alomari M, Dodoo CC, Trenfield SJ, Velaga S, Basit AW, Gaisford S (2018) Personalisation of warfarin therapy using thermal ink-jet printing, European Journal of Pharmaceutical Sciences; 117, 80-87 doi: 10.1016/j.ejps.2018.02.002.

Trenfield SJ, Awad A, Goyanes A, Gaisford S, Basit AW (2018) 3D Printing Pharmaceuticals: Drug Development to Frontline Care, Trends in pharmacological sciences; 39(5), 440-451 doi: 10.1016/j.tips.2018.02.006

Awad A (joint first author), Trenfield SJ (joint first author), Goyanes A, Gaisford S, Basit AW (2018) Reshaping drug development using 3D printing, Drug Discovery Today; 23(8), 1547-1555 https://doi.org/10.1016/j.drudis.2018.05.025

Awad A, Trenfield SJ, Gaisford S, Basit AW (2018) 3D printed medicines: A new branch of digital healthcare,  International Journal of Pharmaceutics; 548(1), 586-596 https://doi.org/10.1016/j.ijpharm.2018.07.024

Alomari M, Vuddanda PR, Trenfield SJ, Dodoo CC, Velaga S, Basit AW, Gaisford S (2018) Printing T3 and T4 oral drug combinations as a novel strategy for hypothyroidism, International Journal of Pharmaceutics; 549(1-2), 363-369 doi: 10.1016/j.ijpharm.2018.07.062.

Trenfield SJ, Goyanes A, Telford R, Wilsdon D, Rowland M, Gaisford S, Basit AW (2018) 3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach, International Journal of Pharmaceutics; 549(1-2), 283-292 https://doi.org/10.1016/j.ijpharm.2018.08.002

Fina F, Goyanes A, Madla CM, Awad A, Trenfield SJ, Kuek JM, Gaisford S, Basit AW (2018) 3D printing of drug-loaded gyroid lattices using selective laser sintering, International Journal of Pharmaceutics; 547(1-2), 44-52 doi: 10.1016/j.ijpharm.2018.05.044.

 

EPSRC Centres for Doctoral Training in Advanced Therapeutics and Nanomedicines

 

The University of Nottingham
School of Pharmacy
Boots Science Building
University of Nottingham,
Nottingham, NG7 2RD
t: +44(0)115 823 2121
e: Claudia.Matz@nottingham.ac.uk

University College London
School of Pharmacy
University College London
29-39 Brunswick Square,
London WC1N 1AX.
t: +44 (0) 20 7753 5948
e: s.marks.pharm@ucl.ac.uk