CDT student, UCL School of Pharmacy
PhD Project Title: Microparticles for Enhancing Adoptive T Cell Therapy for Cancer
Supervisor: Dr Gareth Williams
Project description: This PhD project investigates a novel approach for adoptive cell therapy that involves using biodegradable, biocompatible TIPS microparticles to stimulate a targeted, tumour-specific effector response and expansion of T cells in the immunosuppressive tumour microenvironment. If successful, the proposed technology will provide a step-change for adoptive cell therapy by improving tumour immunity and reducing the risk of toxicities that arise from on-target/off-tumour cross reactivity. The first part of the project focuses on the particle design, fabrication and characterisation.
Bowles BJ, Dziemidowicz K, Lopez FL, Orlu M, Tuleu C, Edwards AJ, Ernest TB (2018) Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability, AAPS PharmSciTech. DOI: 10.1208/s12249-018-1090-4.
Dziemidowicz K, Lopez FL, Bowles BJ, Edwards AJ, Ernest TB, Orlu M, Tuleu C (2018) Co-Processed Excipients for Dispersible Tablets–Part 2: Patient Acceptability, AAPS PharmSciTech; DOI: 10.1208/s12249-018-1104-