EPSRC Centre for Doctoral Training in Advanced Therapeutics and Nanomedicines

 
University of Nottingham
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Christine Madla

CDT student, UCL School of Pharmacy

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Christine Madla
 
Biography

Christine received her BSc in Pharmaceutical Science from the University of Greenwich with First Class Honours. Following an internship at the Estée Lauder Companies in both the manufacturing and quality assurance departments, she graduated with a Distinction in MSc Pharmaceutical Formulation and Entrepreneurship at the UCL School of Pharmacy. Christine undertook a year working as a Medical Writer in the Basit Research Group at the UCL School of Pharmacy spanning the research of personalised medicines, advanced pharmaceutical manufacturing techniques and gastrointestinal drug delivery. Christine began the CDT programme at UCL in 2018 and completed two mini-projects. Her first three-month project was entitled “Absolute Characterisation of Intestinal P-glycoprotein Expression in Male and Female Sprague Dawley rats”. Christine then completed an industry placement at AstraZeneca in Cambridge where she developed “Analytical Methodologies for the Characterisation of Nanomedicines for Oncology Targeting”. Christine is now working towards her PhD in understanding why males and females respond differently to medicines following oral drug administration under the academic supervision of Professor Abdul Basit and Dr Sudax Murdan at the UCL School of Pharmacy and is in affiliation with Dr Sadia Rahman and Nicola Clear from Pfizer Global Research and Development. 

 
Current Research

PhD Project Title: Are excipients inert? Investigating the biopharmaceutics of excipients and their potential sex-dependency on oral drug bioavailability

Supervisor: Prof Abdul Basit

Christine’s PhD is focussed on understanding why males and females respond differently to medicines following oral drug absorption and seeks to manufacture sex-specific formulations via conventional pharmaceutical manufacture techniques. The main research aims of Christine’s project include i) the exploration of the interaction of excipients with intestinal P-glycoprotein to influence oral drug absorption; ii) to produce a comprehensive portfolio of excipients that can pharmacologically increase oral drug bioavailability to improve the Biopharmaceutical Drug Disposition Classification System and; iii) to improve patient-specific predictions and medicines by manufacturing personalized, sex-specific oral dosage forms. The output of this research can have significant implications for the development of novel materials and sex-specific formulations to provide an improved therapeutic index for oral medicines. 

 
Publications

Automated therapy prepation of isoleucine formulations using 3D printing for the treatment of MSUD: first single-centre, prospective, crossover study in patients, A Goyanes, CM Madla, A Umerji, GD Piñeiro, JMG Montero, MJL Diaz, MG Barcia, F Taherali, P Sánches-Pintos, ML Couce, S Gaisford, AW Basit. Int J Pharm. 2019, 4:118497

Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase. Oral Drug Bioavailability in Male but not Female Rats. Y Mai, L Dou, CM Madla, S Murdan, AW Basit. 2019, Pharmaceutics 11 (5), 228

The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group. M Koziolek, S Alcaro, P Augustijns, AW Basit, M Grimm, B Hens, CL Hoad. et al. Eur J Pharm Sci. 2019, 134, 31-59

Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption, GB Hatton, CM Madla, SC Rabbie, AW Basit. Drug Discov Today. 2019, 24(2), 417-427

Fabricating 3D printed orally disintegrating printlets using selective laser sintering, F Fina, CM Madla, A Goyanes, J Zhang, S Gaisford, AW Basit. Int J Pharm. 2018, 541 (1-2), 101-107

3D printing of drug-loaded gyroid lattices using selective laser sintering, F Fina, A Goyanes, CM Madla, A Awad, SJ Trenfield, JM Kuek, P Patel et al. Int J Pharm. 2018, 547 (1-2), 44-52

All disease begins in the gut: Influence of gastrointestinal disorders and surgery on oral drug performance. GB Hatton, CM Madla, SC Rabbie, AW Basit. Int J Pharm. 2018, 548(1), 408-422

Sex differences in the gastrointestinal tract of rats and the implications for oral drug delivery. F Afonso-Pereira, L Dou, SJ Trenfield, CM Madla, S Murdan, J Sousa et al. Eur J Pharm Sci. 2018, 115, 339-344

3D Printing Technologies, Implementation and Regulation: An Overview, CM Madla, SJ Trenfield, A Goyanes, S Gaisford, AW Basit. 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series, 2018, 31, 21-40

Binder Jet Printing in Pharmaceutical Manufacturing, SJ Trenfield, CM Madla, AW Basit, S Gaisford. 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series, 2018, 31, 41-54

The Shape of Things to Come: Emerging Applications of 3D Printing in Healthcare, SJ Trenfield, CM Madla, AW Basit, S Gaisford. 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series, 2018, 31, 1-19

Medical Applications of 3D Printing, GB Hatton, CM Madla, S Gaisford, AW Basit. 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series, 2018, 31, 163-182

P-glycoprotein expression in the gastrointestinal tract of male and female rats is influenced differently by food. L Dou, Y Mai, CM Madla, M Orlu, AW Basit. Eur J Pharm Sci. 2018, 123, 569-575

 

EPSRC Centres for Doctoral Training in Advanced Therapeutics and Nanomedicines

 

The University of Nottingham
School of Pharmacy
Boots Science Building
University of Nottingham,
Nottingham, NG7 2RD
t: +44(0)115 823 2121
e: Claudia.Matz@nottingham.ac.uk

University College London
School of Pharmacy
University College London
29-39 Brunswick Square,
London WC1N 1AX.
t: +44 (0) 20 7753 5948
e: s.marks.pharm@ucl.ac.uk